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KMID : 0877219980020020121
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Journal of Korean Epilepsy Society
1998 Volume.2 No. 2 p.121 ~ p.126
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Dynorphin-immunoreactivity Patterns of Hippocampus in Patients with Intractable Temporal Lobe Epilepsy with Hippocampal Sclerosis
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Kim Jang-Sung
Kim Jung-Sun
Joo Hee-Jae
Sim Chul
Cho Kyung-Gi
Huh Kyoon
Seo Joong-Seok
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Abstract
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Background : Dynorphin (DYN) is one of neuropeptides widely distributed in primate brain. In human mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS), DYN-immunoreactivity (DYNIR) band in inner molecular layer of hippocampal dentate gyrus (DGIML) is a well-known immunohistochemical feature, whereas DYNIR is present in axonal terminals of dentate granular neurons (DGNs) in normal hippocampus. We evaluated DYNIR patterns in resected hippocampal specimens of Korean TLE patients with HS.
Methods : Eleven hippocampal specimens resected from 11 intractable TLE patients tilth HS on MRI were available for immunohistochemical staining for dynorphin-A. Nine hippocampal specimens from autopsied controls were also evaluated for DYNIR. In either cases, we investigated patterns of DYNIR in neuronal fibers of all sectors. In hippocampus from CA1 to dentals gyrus.
Results : Five patterns of DYNIR were demonstrated as follows : 1) Pattern Ⅰ : Four crises showed a typical pattern with DYNIR band in DGIML without demonstrating immunoreactivity in any other region. 2) Pattern Ⅱ : Four closes demonstrated DYNIR in hilus as well as DGIML. 3) Pattern Ⅲ : In one case, DYNIR appeared in DGIML, hilus and CA3. 4) Pattern Ⅳ : In one, only hilus and CA3 were immunoreactive to dynorphin. 5) Pattern Ⅴ : The last one showed a combination of pattern Ⅲ and no DYNIR at the opposite blade of DG. In normal hippocampal specimen, DYNIR was shown in hilus and at stratum lucidum along CA3 region.
Conclusion : Previous studios have been emphasizing the typical pattern Ⅰ.However, the result of this study argues that patterns of DYNIR are variable in intractable TLE with HS.
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KEYWORD
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Temporal lobe epilepsy, Hippocampal sclerosis, Dynorphin-immunoreactivity
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